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Ibuprofen: Quiz


Question 1:
What is the chemical name of Ibuprofen (IUPAC)
sodium 3-propanoate
-2-propanoic acid
2-propanoic acid

Question 2: [2] It was discovered by Andrew RM Dunlop, with colleagues Stewart Adams, John Nicholson, Jeff Wilson & Colin Burrows and was ________ in 1961.
PatentPatent applicationPatent infringementSoftware patent

Question 3: Non-steroidal anti-inflammatory drugs such as ibuprofen work by inhibiting the enzyme cyclooxygenase (COX), which converts ________ to prostaglandin H2 (PGH2).
EicosanoidArachidonic acidEicosapentaenoic acidLipoxin

Question 4:
What is the molecular weight of Ibuprofen?
211.219 g/mol
301.72438 g/mol
146.091 kDa

Question 5: Ibuprofen was derived from propionic acid by the research arm of ________ during the 1960s.
HalfordsBoots GroupUnited KingdomAlliance Boots

Question 6: Reaction with ethyl chloroacetate (Darzens reaction) gave the α,β-epoxy ________, which was decarboxylated and hydrolyzed to the aldehyde.
AlkaneEsterCarboxylic acidAlcohol

Question 7:
What is the melting point of Ibuprofen?

Question 8:
How is Ibuprofen excreted?
faecal 47%
Renal 13u201325%, biliary 50u201360%
Fecal and renal

Question 9: It is used for relief of symptoms of arthritis, primary dysmenorrhea, fever, and as an ________, especially where there is an inflammatory component.
AnalgesicNon-steroidal anti-inflammatory drugStimulantDissociative

Question 10: Infrequent adverse effects include: esophageal ulceration, heart failure, ________, renal impairment, confusion, and bronchospasm.
Diabetic ketoacidosisHyperkalemiaRenal tubular acidosisHypokalemia

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