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Hydrocodone: Quiz


Question 1: The particular niche in which hydrocodone is most commonly used is as an intermediate centrally acting analgesic and strong cough suppressant, especially in those for whom ________ release and attendant itching from codeine is a problem.

Question 2:
What is the molecular weight of Hydrocodone?
392.92 g/mol

Question 3:
What is the elimination half life of Hydrocodone?
2 to 3 hours
5-6 hours
3.5 - 5 hours
3.8 - 6 hours

Question 4:
How is Hydrocodone excreted?
faecal 47%
Biliary, renal
Renal: 93%

Question 5:
What is the chemical name of Hydrocodone (IUPAC)
-7,8-Didehydro- 4,5-epoxy- 17-methylmorphinan- 3,6-dipropionate

Question 6: Symptoms of hydrocodone overdose include respiratory depression; extreme somnolence; blue, clammy, or cold skin; narrowed or widened pupils; ________; coma; seizures; cardiac arrest; and death.
Myocardial infarctionBradycardiaAtrial fibrillationTachycardia

Question 7: Some of the effects of hydrocodone come from the fact that a fraction of it is changed to hydromorphone in the liver, as is the case with all codeine-based analgesics (________ into morphine, dihydrocodeine into dihydromorphine, nicocodeine into nicomorphine etc.).

Question 8: ________, nefopam, carisoprodol, and antihistamines also potentiate most opioids.

Question 9: [4] Studies have shown hydrocodone to be approximately equal to the strength of ________.

Question 10: Therefore the risk of fatal overdose due to ________ can occur with significantly lower levels of APAP when mixed with ethanol.
AspirinHepatitisAcute liver failureHepatotoxicity

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