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Hydrochlorothiazide: Quiz


Question 1:
How is Hydrochlorothiazide excreted?
70-90% unchanged in urine, 1.3ml/kg/min t1/2 2- 4 hours
Renal 40u201350% ,
faecal 47%
Primarily excreted unchanged in urine

Question 2:
What is the elimination half life of Hydrochlorothiazide?
24-36 h
1u20134 h
5–10 h
5.6-14.8 h

Question 3: It is effective for nephrogenic ________ and is also sometimes used for hypercalciuria, Dent's disease and Meniere's disease.
Liddle's syndromeDiabetic nephropathyDiabetes insipidusBartter syndrome

Question 4: HCTZ is often used in the treatment of hypertension, congestive heart failure, symptomatic ________ and the prevention of kidney stones.

Question 5:
What is the chemical name of Hydrochlorothiazide (IUPAC)
-11-hydroxy-3,20-dioxo-21-pregn-4-en-17-yl butyrate

Question 6:
What is the molecular weight of Hydrochlorothiazide?
209.24 g/mol
494.525 g/mol
1148.403 g/mol

Question 7: ________, an occasional side effect, can be usually prevented by potassium supplements or by combining hydrochlorothiazide with a potassium-sparing diuretic.
HypokalemiaRenal tubular acidosisDiabetic ketoacidosisHyperkalemia

Question 8: Hydrochlorothiazide, abbreviated HCTZ, HCT, or HZT, is a first line ________ drug of the thiazide class that acts by inhibiting the kidneys' ability to retain water.
Antihypertensive drugCalcium channel blockerDiureticBeta blocker

Question 9: This reduces the volume of the ________, decreasing blood return to the heart and thus cardiac output and, by other mechanisms, is believed to lower peripheral vascular resistance.
Red blood cellPlateletBloodBlood plasma

Question 10: Hydrochlorothiazide belongs to the thiazide class of ________, acting on the kidneys to reduce sodium (Na) reabsorption in the distal convoluted tubule.
Calcium channel blockerDiureticBeta blockerAntihypertensive drug

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