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Hepatotoxicity: Quiz

  
  

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Question 1: In ________, however, the initial insult can be fatal.
Paracetamol toxicityEthylene glycol poisoningCarbon monoxide poisoningLead poisoning

Question 2: ________ is usually divided into two phases: phase 1 and phase 2.
PharmacogeneticsADMEDrug metabolismPharmacology

Question 3: [25] In normal circumstances this metabolite is detoxified by conjugating with ________ in phase 2 reaction.
MethionineAdenosine triphosphateEthanolGlutathione

Question 4: A group of enzymes located in the endoplasmic reticulum, known as ________, is the most important family of metabolizing enzymes in the liver.
Cytochrome P450CYP3A4Aromatase21-Hydroxylase

Question 5: This is the most common type of drug induced liver cell ________ where the injury is largely confined to a particular zone of the liver lobule.
InflammationNecrosisAutopsyHistopathology

Question 6: Troglitazone, bromfenac, trovafloxacin, ebrotidine, ________, nefazodone, ximelagatran and pemoline.
PiroxicamDiclofenacAspirinNimesulide

Question 7: Administration of ________, a precursor of glutathione, can limit the severity of the liver damage by capturing the toxic NAPQI.
NaloxoneDextromethorphanPsychotria ipecacuanhaAcetylcysteine

Question 8: [20][21] This is because it requires significant damage to the liver to impair bilirubin excretion, hence minor impairment (in the absence of biliary obstruction or ________) would not lead to jaundice.
Variegate porphyriaGilbert's syndromeCrigler-Najjar syndromePorphyria cutanea tarda

Question 9: [27] Aspirin and ________ are associated with intrinsic hepatotoxicity; idiosyncratic reaction has been associated with ibuprofen, sulindac, phenylbutazone, piroxicam, diclofenac and indomethacin.
KetoprofenNaproxenIndometacinPhenylbutazone

Question 10: [11] Injury to hepatocyte and bile duct cells lead to accumulation of ________ inside liver.
Bile acidCholic acidCholesterolMetabolism
















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