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Henoch–Schönlein purpura: Quiz


Question 1: Biopsy of the ________ may be performed both to establish the diagnosis or to assess the severity of already suspected kidney disease.
LiverEndocrine systemKidneyUrinary system

Question 2: The majority of the serines and the threonines have elaborate sugar chains, connected through ________ atoms (O-glycosylation).

Question 3: While abnormalities on urinalysis may continue for a long time, only 1% of all HSP patients develop ________.
Acute kidney injuryDiabetic nephropathyChronic kidney diseaseRenal failure

Question 4: The main findings on kidney biopsy are increased cells and Ig deposition in the mesangium (part of the glomerulus, where blood is filtered), ________, and the development of crescents.
Eosinophil granulocytePhagocyteNeutrophil granulocyteWhite blood cell

Question 5: Treatment may be indicated on the basis of the appearance of the biopsy sample; various treatments may be used, ranging from oral steroids to a combination of intravenous methylprednisolone (steroid), ________ and dipyridamole followed by prednisone.

Question 6: [9] The joints involved tend to be the ankles, knees, and ________ but arthritis in the hands and feet is possible; the arthritis is non-erosive and hence causes no permanent deformity.
Upper limbWristElbowShoulder

Question 7: One of the characteristics of IgA1 (and IgD) is the presence of an 18 ________-long hinge region between complement-fixating region 1 and 2.
L-DOPAAmino acidMetabolismAmino acid synthesis

Question 8: In end-stage renal disease, some eventually need ________ or equivalent renal replacement therapy (RRT).
ICD-9-CM Volume 3HemofiltrationHemodialysisSurgery

Question 9: More than half also have proteinuria (protein in the urine), which in one eighth is severe enough to cause ________ (generalised swelling due to low protein content of the blood).
Nephrotic syndromeFocal segmental glomerulosclerosisChronic kidney diseaseRenal tubular acidosis

Question 10: These antibodies are of the subclass IgA1 in polymers; it is uncertain whether the main cause is overproduction (in the digestive tract or the ________) or decreased removal of abnormal IgA from the circulation.
Immune systemBone marrowHematopoietic stem cellLymphatic system


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