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Hemoglobinopathy: Quiz

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Question 1: Hemoglobin variants are a part of the normal embryonic and fetal development, but may also be pathologic mutant forms of hemoglobin in a ________, caused by variations in genetics.
World populationOverpopulationPopulation growthPopulation

Question 2: Micro-: ________ (Plummer-Vinson syndrome)
Serum ironHenoch–Schönlein purpuraIron deficiency anemiaSickle-cell disease

Question 3: [2] Common hemoglobinopathies include ________.
AnemiaHaemophiliaSickle-cell diseaseGlucose-6-phosphate dehydrogenase deficiency

Question 4: Some well-known hemoglobin variants such as ________ are responsible for diseases, and are considered hemoglobinopathies.
HaemophiliaGlucose-6-phosphate dehydrogenase deficiencyHemolytic anemiaSickle-cell disease

Question 5: Some hemoglobinopathies (and also related diseases like ________) seem to have given an evolutionary benefit, especially to heterozygotes, in areas where malaria is endemic.
Haemophilia BSideroblastic anemiaHaemophilia AGlucose-6-phosphate dehydrogenase deficiency

Question 6: [3] ________, in contrast, usually result in underproduction of normal globin proteins, often through mutations in regulatory genes.
HaemophiliaThalassemiaSickle-cell diseaseSickle cell trait

Question 7: Hemoglobinopathy is a kind of genetic defect that results in abnormal structure of one of the globin chains of the ________ molecule.
Arterial blood gasHemoglobinSerum ironGlycated hemoglobin

Question 8: Other variants cause no detectable ________, and are thus considered non-pathological variants.
Infectious diseaseInfectionDiseasePathology

Question 9: Most clinically significant hemoglobinopathies cause mild to acute ________, in rare cases hemolytic anemia.
Iron deficiency anemiaPernicious anemiaAnemiaAplastic anemia







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