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Glucose-6-phosphate dehydrogenase deficiency: Quiz


Question 1: purine-pyrimidine metabolism: ________
Pelizaeus-Merzbacher diseaseGlucose-6-phosphate dehydrogenase deficiencyLesch–Nyhan syndromeHunter syndrome

Question 2: The diagnosis is generally suspected when patients from certain ethnic groups (see epidemiology) develop ________, jaundice and symptoms of hemolysis after challenges from any of the above causes, especially when there is a positive family history.
Pernicious anemiaIron deficiency anemiaAplastic anemiaAnemia

Question 3: One theory to explain this, is that cells infected with the Plasmodium parasite are cleared more rapidly by the ________.
Lymphatic systemImmune systemSpleenStomach

Question 4: Prolonged ________, possibly leading to kernicterus (arguably the most serious complication of G6PD deficiency)
PneumothoraxPolycythemiaNeonatal jaundiceNecrotizing enterocolitis

Question 5: [1][3][4] ________ has been known to cause haemolytic crisis in G6PD-deficient infants.
Phyllanthus emblicaRed hairTurmericHenna

Question 6: People with G6PD deficiency are therefore at risk of ________ in states of oxidative stress.
Glucose-6-phosphate dehydrogenase deficiencySpherocytosisParoxysmal nocturnal hemoglobinuriaHemolytic anemia

Question 7: Glucose-6-phosphate dehydrogenase (G6PD) is an ________ in the pentose phosphate pathway (see image, also known as the HMP shunt pathway).
Enzyme inhibitorProteinCofactor (biochemistry)Enzyme

Question 8: Very severe crises can cause ________
Chronic kidney diseaseRenal tubular acidosisAcute kidney injuryKidney stone

Question 9: Micro-: ________ (Plummer-Vinson syndrome)
Henoch–Schönlein purpuraIron deficiency anemiaSickle-cell diseaseSerum iron

Question 10: ________ against some common pathogens (e.g.
VaccineSmallpox vaccineVaccinationPolio vaccine


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