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Gilbert's syndrome: Quiz


Question 1: Cholestasis can be excluded by the absence of lactate dehydrogenase, low levels of conjugated bilirubin and ________ scan of the bile ducts.
AcousticsUltrasoundLiverMedical ultrasonography

Question 2: The enzymes that are defective in GS (UGT1A1) are also responsible for some of the ________'s ability to detoxify certain drugs.
Immune systemEndocrine systemLiverPancreas

Question 3: ________, Nobel laureate in Physiology or Medicine, 1959[31]
David BaltimoreArthur KornbergMarshall Warren NirenbergJames D. Watson

Question 4: The main symptom is otherwise harmless jaundice, which does not require treatment, caused by elevated levels of unconjugated bilirubin in the bloodstream (________).

Question 5: The level of total bilirubin is often increased if the blood sample is taken after ________ for two days[21], and a fast can therefore be useful diagnostically.
EasterLiturgical yearJesusFasting

Question 6: [19] in 1977, proposed that ________ was creating the false impression that GS had a definitive, frequent set of symptoms.
Selection biasConfirmation biasCognitive biasSampling bias

Question 7: ________ can be excluded by negative blood samples for antigens specific to the different hepatitis vira.
Hepatocellular carcinomaRotavirusViral hepatitisHepatitis C

Question 8: Conjugation renders the bilirubin water-soluble, after which it is excreted in ________ into the duodenum.
Human gastrointestinal tractSecretinBileDigestion

Question 9: If the total bilirubin does in fact increase while fasting, the patient can then be given low doses of ________[22] when fasting has ended, and following samples should show a decrease in total bilirubin toward normal levels.

Question 10: The cause of this hyperbilirubinemia is the reduced activity of the ________ glucuronyltransferase, which conjugates bilirubin and some other lipophilic molecules.
EnzymeEnzyme inhibitorCofactor (biochemistry)Protein


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