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Fluvoxamine: Quiz

  
  

Question 1: It has negligible affinity for the ________ or any other receptor, with the sole exception of the sigma-σ1 receptor.
Dopamine transporterVesicular monoamine transporter 2Vesicular monoamine transporterVesicular monoamine transporter 1

Question 2:
What is the chemical name of Fluvoxamine (IUPAC)
O--L-serine
1,3,4,6-tetrakis-O--u03B2--fructofuranose
-5-methoxy-1-4-(trifluoromethyl)phenylpentan-1-one O-2-aminoethyl oxime
'2-methyl-3-o-tolyl-4-quinazolinone;

Question 3:
What is the molecular weight of Fluvoxamine?
466.551 g/mol
666.894 g/mol
318.335
301.72438 g/mol

Question 4: Fluvoxamine has a low potential for the drug interactions which are based on inhibition of enzyme Cytochrome P450 ________.
CYP3A4CYP2E1CYP2D621-Hydroxylase

Question 5: Fluvoxamine inhibits metabolism of diazepam and phenytoin via ________ and metabolism of aripiprazole, chlorpromazine, clozapine, haloperidol, olanzapine, perphenazine, risperidone, thioridazine and zuclopenthixol via CYP2D6 as well as of aripiprazole, clozapine, haloperidol, quetiapine, risperidone and ziprasidone via CYP3A4.
CYP2B6CYP1A2CYP2C19CYP2A6

Question 6: Of major concern is the fact that the ________ found in tobacco smoke are potent inducers of CYP1A2 so that smokers may require significant modification of medication dosage.
Polycyclic aromatic hydrocarbonHigh-fructose corn syrupFormaldehydeLead poisoning

Question 7: Fluvoxamine has the shortest ________ of all SSRIs; its mean serum half-life is 15.6 hours.
Half-lifeCosmic rayNuclear fissionRadioactive decay

Question 8: codeine, morphine, tramadol) and ________ (eg.
OlanzapineChlorpromazineAntiparkinsonAntipsychotic

Question 9: Fluvoxamine may help in the treatment of ________.
ConstipationIrritable bowel syndromeCrohn's diseaseCoeliac disease

Question 10: Fluvoxamine does, however, inhibit cytochrome P450 enzyme ________, which metabolises agomelatine, caffeine, clozapine, haloperidol, phenacetin, tacrine, theophylline, and olanzapine.
CYP3A4CYP1A2CYP2C19CYP2D6
















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