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Fluoxetine: Quiz

  
  

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Question 1: [24][25] More rarely, fluoxetine has been associated with related movement disorders acute ________ and tardive dyskinesia.
DystoniaParkinson's diseaseAlzheimer's diseaseParkinsonism

Question 2: Fluoxetine and norfluoxetine inhibit many isozymes of the ________ system that make drug metabolism possible.
AromataseCytochrome P450CYP3A421-Hydroxylase

Question 3: Fluoxetine (trade name Prozac) is an ________ of the selective serotonin reuptake inhibitor (SSRI) class.
AnxiolyticStimulantMirtazapineAntidepressant

Question 4:
What is the chemical name of Fluoxetine (IUPAC)
-N-methyl-1-phenyl-propan-2-amine
-N-methyl-3-phenyl-3-(trifluoromethyl)phenoxypropan-1-amine
-N-methyl-1-phenyl-N-prop-2-ynyl-propan-2-amine
-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine

Question 5: A ________ published in February 2008 combined 35 clinical trials of four newer antidepressants (fluoxetine, paroxetine (Paxil), nefazodone (Serzone) and venlafaxine (Effexor)).
Effect sizeStatistical hypothesis testingForest plotMeta-analysis

Question 6:
How is Fluoxetine excreted?
Lactic
Kidneys 80%, intestines 15%
70-90% unchanged in urine, 1.3ml/kg/min t1/2 2- 4 hours
Renal: 93%

Question 7:
What is the elimination half life of Fluoxetine?
1-3 days ; 4-6 days ; Active metabolite Norfluoxetine 4-16 days
1.3 to 1.7 hours
?
2u20133 hours

Question 8: In three double-blind trials fluoxetine significantly decreased the number of binge-eating and purging episodes of ________.
Bulimia nervosaEating disordersMajor depressive disorderAlzheimer's disease

Question 9: Later, hoping to find a derivative inhibiting only serotonin reuptake, another Eli Lilly scientist, David Wong, proposed to re-test the series for the in-vitro reuptake of serotonin, norepinephrine and ________.
DopaminePhenethylamineAmphetamineTyramine

Question 10: A controversy ensued after Lilly researchers published a paper entitled "Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug"[4] claiming fluoxetine to be the first ________ (SSRI).
Tricyclic antidepressantSelective serotonin reuptake inhibitorSertralineMirtazapine
















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