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Fexofenadine: Quiz


Question 1: Fexofenadine, like other second and third-generation antihistamines, does not readily cross the ________, and so causes less drowsiness than first-generation histamine-receptor antagonists.
Blood-brain barrierImmune systemMeningitisAIDS

Question 2:
How is Fexofenadine excreted?
Renal 13u201325%, biliary 50u201360%
Fecal and renal
in feces
Feces, and urine, as unchanged drug

Question 3:
What is the molecular weight of Fexofenadine?
416.511 g/mol
666.894 g/mol
414.496 g/mol

Question 4: The remaining piece of the molecule is produced by a double alkylation by iodomethane of the ________ derived from the nitrile.
Acetic acidOrganic reactionCarbanionOrganic chemistry

Question 5: Since that time, it has achieved blockbuster drug status with global sales of $1.87B USD in 2004 (with $1.49B USD coming from the ________).
PhilippinesAlaskaUnited StatesCanada

Question 6: To produce the piperidine piece, two phenyl groups are first introduced using a ________ on the ester, giving a tertiary alcohol.
Gilman reagentOrganometallic chemistryBeta-Hydride eliminationGrignard reaction

Question 7: The older antihistaminic agent terfenadine was found to metabolize into the related ________, fexofenadine.
EsterCarboxylic acidAlkaneAlcohol

Question 8: Fexofenadine (Allegra, Telfast, Fastofen, Tilfur) is an antihistamine drug used in the treatment of hayfever and similar ________ symptoms.
AnaphylaxisGraft-versus-host diseaseHypersensitivityAllergy

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