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Fas ligand: Quiz


Question 1: FADD also contains a death effector domain (DED) near its amino terminus, which facilitates binding to the DED of ________-like ICE (FLICE), more commonly referred to as caspase-8.
Fas receptorFADDFas ligandCaspase 8

Question 2: FasR: The Fas receptor (FasR), or ________, is the most intensely studied member of the death receptor family.
TNFRSF1AFas ligandFas receptorTNFRSF10B

Question 3: ________: Decoy receptor 3 (DcR3) is a recently discovered decoy receptor of the tumor necrosis factor superfamily that binds to FasL, LIGHT, and TLA1.

Question 4: DcR3 is a soluble receptor that has no signal transduction capabilities (hence a "decoy") and functions to prevent ________-FasL interactions by competitively binding to membrane-bound Fas ligand and rendering them inactive.

Question 5: Its binding with its receptor induces ________.
Signal transductionApoptosisTranscription factorApoptosis-inducing factor

Question 6: Fas ligand has been shown to interact with FADD,[4][5] Grb2,[6][7] ________,[4][5] Fas receptor,[4][5][8][9] FYN,[7][10] VIL2,[4][11] PACSIN2,[6] FNBP1[6] and TNFRSF6B.
Caspase 3Caspase-9Caspase 2Caspase 8

Question 7: Apoptosis-inducing Fas receptor is dubbed isoform 1 and is a type 1 ________.
Integral membrane proteinMembrane receptorPeripheral membrane proteinTransmembrane protein

Question 8: ________ homeostasis: the activation of T-cells leads to their expression of the Fas ligand.
Regulatory T cellCytotoxic T cellT cellT helper cell

Question 9: ________ triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system.
Signal transductionApoptosisTranscription factorApoptosis-inducing factor

Question 10: Fas ligand (FasL or ________L) is a type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family.


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