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Fanconi anemia: Quiz

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Question 1: Many patients eventually develop ________ (AML).
Acute promyelocytic leukemiaChronic myelogenous leukemiaAcute myeloid leukemiaMyelodysplastic syndrome

Question 2: The deficiencies cause increase risk of ________ and recurrent infections, respectively.
Gastrointestinal bleedingBleedingBruisePurpura

Question 3: These changes reflect delayed apoptosis or a failure of ________.
EmbryoFertilisationProgrammed cell deathDevelopmental biology

Question 4: [4] Genetic counseling and ________ is recommended for families that may be carriers of Fanconi anemia.
Genetic discriminationDNACancerGenetic testing

Question 5: Indeed, recent investigations on FANCC, one of the intensively studied proteins, have shown that it plays an important role in cellular responses to ________.
Reactive oxygen speciesAntioxidantRadical (chemistry)Oxidative stress

Question 6: The carrier frequency in the ________ Jewish population is about 1/90.
Sephardi JewsAshkenazi JewsJewish ethnic divisionsJews

Question 7: There are at least 13 genes of which mutations are known to cause FA: ________, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM and FANCN.
Fanconi anemia, complementation group CBRCA2FANCACHUK

Question 8: FANCB is the one exception to FA being autosomal recessive, as this gene is on the ________.
Y chromosomeHuman genomeChromosome 7 (human)X chromosome

Question 9: Because of the failure of hemotologic components to develop - leukocytes, ________ and platelets - the body's capabilities to fight infection, deliver oxygen, and form clots are all diminished.
Red blood cellBlood typeHematologyBlood plasma

Question 10: Also, approximately 50-75% of patients respond to ________, which are used when transplantation is not an option.
EstrogenEstradiolAndrogenTestosterone







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