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Factor VIII: Quiz


Question 1: The transfer of a plasma byproduct into the blood stream of a patient with hemophilia often led to the transmission of diseases such as hepatitis B and C and ________ before purification methods were improved.
AIDSHIVHIV and AIDS misconceptionsSafe sex

Question 2: Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with ________ in a noncovalent complex.
AntithrombinFactor XVon Willebrand factorPlasmin

Question 3: Thrombin cleaves fibrinogen into ________ which polymerizes and crosslinks (using Factor XIII) into a blood clot.

Question 4: In the circulating blood, it is mainly bound to ________ to form a stable complex.
AntithrombinPlasminVon Willebrand factorFactor X

Question 5: Upon activation by ________, (Factor IIa), it dissociates from the complex to interact with Factor IXa in the coagulation cascade.
PlasminFactor XThrombinTissue plasminogen activator

Question 6: No longer protected by vWF, activated FVIII is proteolytically inactivated in the process (most prominently by activated ________ and Factor IXa) and quickly cleared from the blood stream.
Protein SFactor XProtein CPlasmin

Question 7: FVIII concentrated from donated blood plasma (Aafact), or alternatively recombinant FVIII can be given to ________ to restore hemostasis.
Haemophilia AHaemophiliaFanconi anemiaSickle-cell disease

Question 8: [1][2] Defects in this gene results in ________, a well known recessive X-linked coagulation disorder.
Glucose-6-phosphate dehydrogenase deficiencySideroblastic anemiaHaemophilia BHaemophilia A

Question 9: In humans, Factor VIII is encoded by the F8 ________.

Question 10: It is a cofactor to Factor IXa in the activation of ________, which, in turn, with its cofactor Factor Va, activates more thrombin.
Factor XPlasminFactor XITissue plasminogen activator

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