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Factor V: Quiz

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Question 1: The most common one of these, factor V Leiden, is due to the replacement of an ________ residue with glutamine at amino acid position 506 (R506Q).
ArginineLysineGlutamic acidCysteine

Question 2: Factor V has been shown to interact with ________.
Tissue factorProtein CProtein SPlasmin

Question 3: Factor V is able to bind to activated ________ and is activated by thrombin.
Red blood cellBlood plasmaBloodPlatelet

Question 4: Deficiency is associated with a rare mild form of ________ (termed parahemophilia or Owren parahemophilia), the incidence of which is about 1:1,000,000.
Haemophilia ASickle-cell diseaseHaemophiliaFanconi anemia

Question 5: They appeared finally in ________ in 1947.
Medical journalCanadian Medical Association JournalBMJThe Lancet

Question 6: The activated ________ (FXa) enzyme requires Ca++ and activated factor V to convert prothrombin to thrombin on the cell surface membrane.
Factor XTissue plasminogen activatorPlasminFactor XI

Question 7: [3] In 1994 ________, resistant to inactivation by protein C, was described; this abnormality is the most common genetic cause for thrombosis.
Antiphospholipid syndromeHaemophiliaFactor V LeidenThrombophilia

Question 8: Other ________ of factor V are associated with venous thrombosis.
Population geneticsMutationSpeciationEvolution

Question 9: Factor V (pronounced factor 5) is a protein of the ________ system, rarely referred to as proaccelerin or labile factor.
FibrinolysisTissue plasminogen activatorCoagulationPlatelet

Question 10: The ________ for factor V is located on the first chromosome (1q23).
GeneticsGeneEvolutionDNA







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