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Factor IX: Quiz


Question 1: Some rare mutations of factor IX result in elevated clotting activity, and can result in clotting diseases, such as ________.
Pulmonary embolismCerebral venous sinus thrombosisBudd-Chiari syndromeDeep vein thrombosis

Question 2: When activated into factor IXa, in the presence of Ca2+, membrane phospholipids, and a Factor VIII cofactor, it hydrolyses one ________-isoleucine bond in factor X to form factor Xa.
Glutamic acidArginineCysteineLysine

Question 3: It was discovered after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to ________, in 1952.
HaemophiliaFanconi anemiaSickle-cell diseaseHaemophilia A

Question 4: Factor IX (or Christmas factor) is one of the serine proteases (EC of the ________ system; it belongs to peptidase family S1.
Tissue plasminogen activatorFibrinolysisPlateletCoagulation

Question 5: The gene for factor IX is located on the ________ (Xq27.1-q27.2).
Y chromosomeHuman genomeX chromosomeChromosome 7 (human)

Question 6: Polly, a transgenic cloned Poll Dorset sheep carrying the gene for factor IX, was produced by Dr ________ at the Roslin Institute in 1997.
Keith Campbell (biologist)Ian WilmutDavid MumfordAndrew Wiles


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