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Factor H: Quiz


Question 1: ________ (HUS) is a disease associated with microangiopathic haemolytic anemia, thrombocytopenia and acute renal failure.
Escherichia coli O157:H7Waterhouse-Friderichsen syndromeBartonellosisHemolytic-uremic syndrome

Question 2: duttonii; B. recurrentis; ________; Francisella tularensis; Haemophilus influenzae; Neisseria meningitidis; and Streptococcus pyogenes.
Pneumocystis pneumoniaCandidiasisZygomycotaCandida albicans

Question 3: Moreover the complement inhibitory activities of factor H, and other complement regulators, are often used by pathogens to increase ________.
Escherichia coliBacteriaVirulenceInfectious disease

Question 4: Homozygous individuals have an approximately sevenfold increased chance of developing ________, while heterozygotes have a two-to-threefold increased likelihood of developing the disease.
Optic disc drusenMacular degenerationGlaucomaDiabetic retinopathy

Question 5: Its main job is to regulate the Alternative Pathway of the ________, ensuring that the complement system is directed towards pathogens and does not damage host tissue.
Complement systemMannan-binding lectin pathwayClassical complement pathwayAlternative complement pathway

Question 6: CLA: ________ - Decay accelerating factor - Factor I
ProteinComplement component 3C1-inhibitorFactor H

Question 7: It is not surprising therefore that ________ or single nucleotide polymorphisms (SNPs) in factor H often result in pathologies.
Population geneticsSpeciationMutationEvolution

Question 8: Factor H protects self cells from complement activation but not ________/viruses, in that it binds to glycosaminoglycans (GAGs) that are present on host cells but not pathogen cell surfaces.
BacteriaCorynebacteriumGram-positive bacteriaGram-negative bacteria

Question 9: This SNP, located in CCP module 7 of factor H, has been shown to affect the interactions between factor H and both ________ and heparin indicating a causal relationship between the SNP and disease.
C-reactive proteinReference ranges for blood testsSerologyHaptoglobin

Question 10: It is a large (155 kilodaltons), soluble glycoprotein that circulates in human plasma (at a concentration of 500–800 ________ per milliliter).
Metric systemKilogramMass versus weightPlanck constant


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