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Etanercept: Quiz

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Question 1: It mediates the immune response by increasing the transport of white blood cells to sites of ________, and through additional molecular mechanisms which initiate and amplify inflammation.
MeningitisInflammationVasculitisLeukocyte extravasation

Question 2:
What is the molecular weight of Etanercept?
51234.9 g/mol
344.248 g/mol
?
274.440 g/mol

Question 3:
What is the elimination half life of Etanercept?
10u201328 hours
?
70u2013132 hours
2 to 4 hours

Question 4: Etanercept was developed by researchers at Immunex, and was released for commercial use in late 1998, soon after the release of ________ (Remicade) – the first chimeric monoclonal antibody against TNFα to be marketed for clinical use.
NatalizumabInfliximabBasiliximabAdalimumab

Question 5: Inhibition of its action by etanercept reduces the inflammatory response which is especially useful for treating ________.
Immune disorderAutoimmunityAutoimmune diseaseHypersensitivity

Question 6: Enbrel is the most widely used anti-TNF biologic drug in the field of rheumatology with more patients taking this drug for that indication than either Remicade (infliximab) or Humira (________)[citation needed].
UstekinumabGolimumabIpilimumabAdalimumab

Question 7: Etanercept is an example of a protein-based drug created using the tools ________ and conceived through an understanding afforded by modern cell biology.
PharmacologyArchaeologyBioinformaticsBiotechnology

Question 8: In North America, etanercept is co-marketed by Amgen and ________ under the trade name Enbrel in two separate formulations, one in powder form, the other as a pre-mixed liquid.
Combined oral contraceptive pillWyethPfizerMonsanto

Question 9: In addition infliximab has a higher propensity for the development of ________, perhaps as a result both of its chimeric structure and its intravenous route of administration.
AllergyAnaphylaxisGraft-versus-host diseaseSerum sickness

Question 10: It cannot be administered orally, because the ________ would destroy the drug.
StomachEndocrine systemDigestionImmune system







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