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Enzyme inhibitor: Quiz


Question 1: What does the following picture show?

  The structure of a complex between penicillin G and the Streptomyces transpeptidase. Generated from PDB 1PWC.
  Nonpeptidic HIV-1 protease inhibitor tipranavir
  HIV protease in a complex with the protease inhibitor ritonavir. The structure of the protease is shown by the red, blue and yellow ribbons. The inhibitor is shown as the smaller ball-and-stick structure near the centre. Created from PDB 1HXW.
  Reaction of the irreversible inhibitor diisopropylfluorophosphate (DFP) with a serine protease

Question 2: This is a potent enzyme inhibitor, in this case preventing the ________ enzyme from transcribing DNA.
RNA polymerase II holoenzymeRNA polymerase IITelomeraseGlucokinase

Question 3: Enzyme inhibitors are often designed to mimic the ________ or intermediate of an enzyme-catalysed reaction.
Transition stateCatalysisChemical reactionDensity functional theory

Question 4: This catabolic pathway consumes ________ and produces ATP, NADH and pyruvate.

Question 5: This type of negative feedback slows flux through a pathway when the products begin to build up and is an important way to maintain ________ in a cell.
Claude BernardComputational neuroscienceHomeostasisCybernetics

Question 6: A medicinal enzyme inhibitor is often judged by its specificity (its lack of binding to other proteins) and its potency (its ________, which indicates the concentration needed to inhibit the enzyme).
Dissociation constantBinding selectivityAcid dissociation constantChemical equilibrium

Question 7: Natural ________ are often enzyme inhibitors that have evolved to defend a plant or animal against predators.
Lead poisoningMercury poisoningPoisonArsenic poisoning

Question 8: ________ (AChE) is an enzyme found in animals from insects to humans.
IbogaineAcetylcholinesteraseButyrylcholinesteraseCholine acetyltransferase

Question 9: Selective toxicity is also produced in antibiotics by exploiting differences in the structure of the ribosomes in bacteria, or how they make ________.
Butyric acidLinoleic acidFatty acidLipid

Question 10: An example of such a transition state inhibitor is the antiviral drug oseltamivir; this drug mimics the planar nature of the ring oxonium ion in the reaction of the viral enzyme ________.

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