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Dementia with Lewy bodies: Quiz


Question 1: Neurofibrillary tangles (abnormally phosphorylated ________) are less common in DLB, although they are known to occur.
Tau proteinWiskott-Aldrich syndrome proteinDystroglycanGelsolin

Question 2: DLB is thought to be second only to Alzheimer's disease as a cause of ________.
DementiaParkinson's diseaseHuntington's diseaseHypersomnia

Question 3: Unfortunately, several participants in the study had to discontinue treatment because of side-effects -- excessive daytime sleepiness or ________.
Aortic dissectionPulmonary hypertensionHypertensionOrthostatic hypotension

Question 4: [19] Dementia with Lewy bodies only started to be diagnosed in the mid-1990s after the discovery of ________ staining first highlighted Lewy bodies in the cortex of post-mortem brains of a subset of dementia patients.
Alpha-synucleinNerve growth factorBeta-synucleinGap-43 protein

Question 5: Cerebral atrophy (or shrinkage) also occurs as the ________ degenerates.
CerebrumHuman brainGrey matterCerebral cortex

Question 6: [7] DLB patients also often experience problems from ________, including repeated falls, syncope (fainting), and transient loss of consciousness.
Pulmonary hypertensionOrthostatic hypotensionHypertensionHypotension

Question 7: ________ injections in the parotid glands may help with sialorrhea.
EpibatidineToxiferineBotulinum toxinOnchidal

Question 8: [8] Because it was only recently discovered, DLB is not a recognized diagnosis in ________, which was published in 1994.
Mental disorderClassification of mental disordersDiagnostic and Statistical Manual of Mental DisordersSchizophrenia

Question 9: Pathologically, DLB is characterized by the development of abnormal proteinaceous (________) cytoplasmic inclusions, called Lewy bodies, throughout the brain.
Gap-43 proteinAlpha-synucleinBeta-synucleinNerve growth factor

Question 10: People with DLB are at risk for ________, a life-threatening illness, because of their sensitivity to these medications, especially the older Typical antipsychotics such as haloperidol.
Serotonin syndromeParkinson's diseaseRestless legs syndromeNeuroleptic malignant syndrome

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