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DNA repair: Quiz


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Question 1: The types of molecules involved and the mechanism of repair that is mobilized depend on the type of damage that has occurred and the phase of the ________ that the cell is in.
CDKN1BCyclin-dependent kinaseCyclinCell cycle

Question 2: The vast majority of DNA damage affects the ________ of the double helix; that is, the bases themselves are chemically modified.
Amino acidDisulfide bondProtein biosynthesisPrimary structure

Question 3: A critical enzyme in counteracting the toxicity of these species is ________, which is present in both the mitochondria and cytoplasm of eukaryotic cells.
GlucosamineIbuprofenChondroitin sulfateSuperoxide dismutase

Question 4: ________ of bases, such as deamination, depurination and depyrimidination.

Question 5: an irreversible state of dormancy, known as ________

Question 6: The polymerase switching is thought to be mediated by, among other factors, the post-translational modification of the replication processivity factor ________.
HER2/neuERBB3VimentinProliferating Cell Nuclear Antigen

Question 7: The rate of ________ in a particular species (or, more narrowly, in a particular gene) is a function of the rate of mutation.
EvolutionIntroduction to evolutionNatural selectionPopulation genetics

Question 8: When normal repair processes fail, and when cellular ________ does not occur, irreparable DNA damage may occur, including double-strand breaks and DNA crosslinkages.
ApoptosisSignal transductionTranscription factorApoptosis-inducing factor

Question 9: Mitochondrial DNA (mtDNA) is located inside mitochondria ________, exists in multiple copies, and is also tightly associated with a number of proteins to form a complex known as the nucleoid.
Cell (biology)OrganelleCell nucleusMitochondrion

Question 10: Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes ________.
Cell cycleMitosisPreprophaseMeiosis


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