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Cytokine: Quiz


Question 1: The vast majority of these are produced by ________.
Immune systemCytotoxic T cellT helper cellB cell

Question 2: Oversecretion of cytokines can trigger a dangerous syndrome known as a cytokine storm; this may have been the cause of severe adverse events during a clinical trial of ________.
NatalizumabOcrelizumabTGN1412Monoclonal antibodies

Question 3: For instance, to use hormone terminology, the action of cytokines may be autocrine or paracrine in chemotaxis and ________ as a pyrogen.
EndocrinologyThyroidHypopituitarismEndocrine system

Question 4: IL-8 (________) is the only chemokine originally named an interleukin.
Interleukin 6Tumor necrosis factor-alphaCD154Interleukin 8

Question 5: Cytokines have been classed as lymphokines, interleukins, and ________, based on their presumed function, cell of secretion, or target of action.
Fas ligandChemokineCD154B-cell activating factor

Question 6: The term chemokine refers to a specific class of cytokines that mediates chemoattraction (________) between cells.
InflammationChemotaxisBacteriaImmune system

Question 7: ________ (type 2) family, whose members are receptors for IFN β and γ.
Interferon-gammaInterferonPeginterferon alfa-2aInterferon alfa-2b

Question 8: In contrast, classic hormones, such as insulin, are secreted from discrete glands (e.g., the ________).
DigestionPancreasLiverEndocrine system

Question 9: Chemokine receptors, two of which act as binding proteins for HIV (CXCR4 and ________), also belong to this family.

Question 10: It seems to be a paradox that cytokines binding to ________ have a stronger immune effect than the cytokine alone.
AntibodyAutoantibodyImmune systemAdaptive immune system


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