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Coombs test: Quiz


Question 1: The Coombs test was first described in 1945 by ________ immunologists Robin Coombs (after whom it is named), Arthur Mourant and Rob Race.

Question 2: The indirect Coombs test is used in prenatal testing of pregnant women, and in testing ________ prior to a blood transfusion.
PlateletBlood plasmaBloodRed blood cell

Question 3: Animal anti-human antibodies will also bind to human antibodies that may be fixed onto antigens on the surface of ________ (also referred to as RBCs), and in the appropriate test tube conditions this can lead to agglutination of RBCs.
Blood plasmaHematologyPlateletRed blood cell

Question 4: If the serum contains ________ to antigens on the RBC surface, the antibodies will bind onto the surface of the RBCs.
AutoantibodyAdaptive immune systemAntibodyImmune system

Question 5: Both IgM and IgG ________ bind strongly with their antigens.
AutoantibodyAntibodyAdaptive immune systemImmune system

Question 6:
  • ________ (also known as Rh disease)
    Hemolytic disease of the newborn (ABO)Hemolytic disease of the newborn (anti-Kell)Rh diseaseHemolytic disease of the newborn (anti-Rhc)

Question 7: In antenatal care, the IAT is used to screen pregnant women for antibodies that may cause ________.
Neonatal jaundiceRh diseaseHemolytic disease of the newbornBlood type

Question 8: This mechanism could be ________, alloimmunity or a drug-induced immune-mediated mechanism.
HypersensitivityAutoimmune diseaseAutoimmunityCell-mediated immunity

Question 9: Common potentiators include low ionic strength solution (LISS), albumin, polyethylene glycol (PEG), and proteolytic ________.
Enzyme inhibitorProteinEnzymeCofactor (biochemistry)

Question 10: Coombs tests are done on serum from venous blood samples which are taken from patients by ________.
Blood donationIntravenous therapyVenipunctureVacutainer


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