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Complement system: Quiz


Question 1: However, it can be recruited and brought into action by the ________.
Innate immune systemHaematopoiesisThymocyteAdaptive immune system

Question 2: Both C3a and C5a have anaphylatoxin activity, directly triggering degranulation of ________ as well as increasing vascular permeability and smooth muscle contraction.
Eosinophil granulocyteBasophil granulocyteWhite blood cellMast cell

Question 3: [17][18] Moreover, a common single nucleotide polymorphism in factor H (Y402H) has been associated with the common eye disease ________.
GlaucomaDiabetic retinopathyOptic disc drusenMacular degeneration

Question 4: When stimulated by one of several triggers, proteases in the system cleave specific proteins to release ________ and initiate an amplifying cascade of further cleavages.

Question 5: Deficiencies of the terminal pathway predispose to both ________ and infections (particularly Neisseria meningitis, due to the role that the C56789 complex plays in attacking Gram-negative bacteria).
Immune disorderHypersensitivityAutoimmunityAutoimmune disease

Question 6: These proteins are synthesized mainly in the ________, and they account for about 5% of the globulin fraction of blood serum.
Immune systemEndocrine systemPancreasLiver

Question 7: It is part of the ________ called the innate immune system that is not adaptable and does not change over the course of an individual's lifetime.
Toll-like receptorImmune systemAdaptive immune systemLymphatic system

Question 8: Mutations in the complement regulators ________ and membrane cofactor protein have been associated with atypical haemolytic uraemic syndrome.
Factor HProperdinC1-inhibitorComplement component 3

Question 9: Immune Clearance, which removes immune complexes from immune system and deposits them in the ________ and liver.
KidneyLymphatic systemSpleenStomach

Question 10: The three pathways all generate homologous variants of the ________ C3-convertase.
Serine proteaseProteaseAspartate proteaseCysteine protease


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