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Coagulation: Quiz


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Question 1: The coagulation factors are generally serine proteases (________).
ProteinEnzyme inhibitorCofactor (biochemistry)Enzyme

Question 2: Before its withdrawal, ________ was used in some forms of major surgery to decrease bleeding risk and need for blood products.
EpinephrineAprotininAlpha 1-antitrypsinAminocaproic acid

Question 3: ________ is the pathological development of blood clots.
Cerebral venous sinus thrombosisLymphedemaDeep vein thrombosisThrombosis

Question 4: Common: aPTT, PT (also used to determine INR), ________ testing (often by the Clauss method), platelet count, platelet function testing (often by PFA-100).

Question 5: Thrombin and fibrin ________ are used surgically to treat bleeding and to thrombose aneurysms.
PolymerHot melt adhesiveAdhesivePolyurethane

Question 6: In addition, it activates Factors VIII and V and their inhibitor protein C (in the presence of thrombomodulin), and it activates Factor XIII, which forms ________ that crosslink the fibrin polymers that form from activated monomers.
Covalent bondChemical bondAromaticityMetallic bond

Question 7: Quantitative or qualitative deficiency of either may lead to ________ (a tendency to develop thrombosis).
ThrombophiliaAntiphospholipid syndromeDisseminated intravascular coagulationParoxysmal nocturnal hemoglobinuria

Question 8: Of the anticoagulants, warfarin (and related ________) and heparin are the most commonly used.

Question 9: Damage to blood vessel walls exposes subendothelium proteins, most notably ________ (vWF), present under the endothelium.
Von Willebrand factorAntithrombinPlasminFactor X

Question 10: This cleavage is catalyzed by ________ (t-PA), which is synthesized and secreted by endothelium.
UrokinaseStreptokinaseTissue plasminogen activatorAncrod


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