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Clonidine: Quiz

  

Question 1:
How is Clonidine excreted?
70-90% unchanged in urine, 1.3ml/kg/min t1/2 2- 4 hours
biliary
urine
in feces

Question 2:
What is the elimination half life of Clonidine?
4 hours ,
?
12-33 hours
4-5 hours in dogs, 6 hours in cats, 1.5 - 4.5 hours in sheep.

Question 3:
What is the molecular weight of Clonidine?
230.093 g/mol
347.449 g/mol
270.714
248.155 g/mol

Question 4: Clonidine may also cause ________[24]
HypertensionHypotensionPulmonary hypertensionAortic dissection

Question 5:
What is the chemical name of Clonidine (IUPAC)
2-benzyl-4,5-dihydro-1H-imidazole
N--4,5-dihydro-1H-imidazol-2-amine
9-methyl-3-(2-methyl-1H-imidazol-1-yl)methyl-2,3-dihydro-1H-carbazol-4-one
5-hydroxy-1-u03B2--ribofuranosyl-1H-imidazole-4-carboxamide

Question 6: Clonidine's effect on reducing circulating epinephrine by a central mechanism was used in the past as an investigatory test for ________,[27] which is a catecholamine-synthesizing tumor, usually of the adrenal medulla.
PheochromocytomaNeuroblastomaICD-10 Chapter II: NeoplasmsParaganglioma

Question 7: These receptors close a negative feedback loop that begins with descending sympathetic nerves from the brain that control the production of catecholamines (________, also known as adrenaline, and norepinephrine) in the adrenal medulla.
SalbutamolEpinephrineOctopaminePhenethylamine

Question 8: Clonidine therapy should generally be gradually tapered off when discontinuing therapy to avoid ________ from occurring.
BenzodiazepineRebound effectBenzodiazepine withdrawal syndromeHypnotic

Question 9: This binding decreases presynaptic ________ levels, and inhibits the release of norepinephrine (NE).
IronAluminiumCalciumMagnesium

Question 10: [1] Clonidine can be used in the treatment of ________.
Tourette syndromeAsperger syndromeTic disorderMajor depressive disorder
















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