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Clomipramine: Quiz

  

Question 1: If medical reasons dictate an immediate termination of treatment, a short-term course of ________ (up to four weeks as needed) will usually suppress the unpleasant withdrawal symptoms.
BenzodiazepineGABA reuptake inhibitorBarbexaclonePropofol

Question 2: Clomipramine's affinity for the DAT is very low/negligible and it therefore lacks any significant ________ actions.
Norepinephrine-dopamine reuptake inhibitorTricyclic antidepressantMonoamine oxidase inhibitorDopamine reuptake inhibitor

Question 3:
What is the chemical name of Clomipramine (IUPAC)
-3-1benzofuro3,2-c1benzoxepin-6-ylidene-N,N-dimethylpropan-1-amine
N,N-diisopropyl-3,3-diphenylpropan-1-amine
3--N,N-dimethyl-3-pyridin-2-yl-propan-1-amine
3--N,N-dimethylpropan-1-amine

Question 4: It was developed in the 1960s by the Swiss drug manufacturer Geigy (now known as ________) and has been in clinical use worldwide ever since.
SyngentaNestléHoffmann–La RocheNovartis

Question 5:
What is the elimination half life of Clomipramine?
1.4 hrs
7 to 14 hours
Desmethylclomipramine, ~50 hours
21-23 hours

Question 6: Interactions with OTC medications against colds and sleeping aids with ________, doxylamine and St. John's wort may occur.
DizocilpineIbogaineDextromethorphanDiphenhydramine

Question 7: Preexisting bone marrow depression (leukopenia, thrombocytopenia, ________, pancytopenia), can be worsened by clomipramine
Iron deficiency anemiaAplastic anemiaPernicious anemiaAnemia

Question 8: Along with ________, clomipramine is a frequently prescribed drug for the treatment of OCD.
Serotonin reuptake inhibitorTricyclic antidepressantMirtazapineSelective serotonin reuptake inhibitor

Question 9: States of confusion (caution), absolutely contraindicated in patients with coma and ________
Delirium tremensBenzodiazepine withdrawal syndromeAlcohol withdrawal syndromeBenzodiazepine dependence

Question 10: modafinil, ________ or methylphenidate) is used in lieu of, or in addition to, a tricyclic antidepressant like clomipramine.
LisdexamfetamineSelegilineMethamphetamineDextroamphetamine
















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