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Cholangiocarcinoma: Quiz

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Question 1: Colonization with the liver flukes Opisthorchis viverrini (found in Thailand, Laos, and Malaysia) or Clonorchis sinensis (found in ________, Korea, and Vietnam) has been associated with the development of cholangiocarcinoma.
JapanCambodiaUnited KingdomCanada

Question 2: ________, cholangiocarcinomas may vary from undifferentiated to well-differentiated.
AstrocyteMicrogliaCostamereHistology

Question 3: hepatitis B or C),[16][17][18] alcoholic liver disease, or ________ from other causes, are at increased risk of cholangiocarcinoma.
Hepatic encephalopathyCirrhosisAcute liver failureHepatorenal syndrome

Question 4: The majority of cases of cholangiocarcinoma present as inoperable (unresectable) disease[65] in which case patients are generally treated with palliative ________, with or without radiotherapy.
ChemotherapyCancer immunotherapyATC code LAntineoplastic

Question 5: A cholangiocarcinoma occurring at the junction where the left and right hepatic ducts meet to form the common bile duct may be referred to ________ as a Klatskin tumor.
EponymJulius CaesarDoriansScientific phenomena named after people

Question 6: Chemotherapy has been shown in a randomized controlled trial to improve ________ and extend survival in patients with inoperable cholangiocarcinoma.
Quality of lifeBhutanGavin NewsomGenuine progress indicator

Question 7: Although ERCP is an invasive procedure with attendant risks, its advantages include the ability to obtain ________ and to place stents or perform other interventions to relieve biliary obstruction.
BiopsyHepatitisCirrhosisLiver

Question 8: [31][32][33] Cholangiocarcinoma is thought to develop through a series of stages — from early hyperplasia and metaplasia, through dysplasia, to the development of frank carcinoma — in a process similar to that seen in the development of ________.
Colorectal cancerHepatocellular carcinomaCrohn's diseaseStomach cancer

Question 9: [71] A small pilot study suggested possible benefit from the tyrosine kinase inhibitor ________ in patients with advanced cholangiocarcinoma.
ErlotinibBevacizumabLapatinibImatinib

Question 10: If the tumor can be removed surgically, patients may receive adjuvant ________ or radiation therapy after the operation to improve the chances of cure.
Cancer immunotherapyAntineoplasticChemotherapyATC code L







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