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Chloroquine: Quiz

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Question 1:
What is the chemical name of Chloroquine (IUPAC)
-1--N-hydroxyl-N-methylpropan-2-amine
N'--N,N-diethyl-pentane-1,4-diamine
4-chloro-N-benzenesulfonamide
5-(1R,2S,3S,5S)-3--8-methyl-8-azabicyclo3.2.1octan-2-yl]-3--1,2-oxazole

Question 2: To avoid destruction by this molecule, the parasite biocrystallizes heme to form ________, a non-toxic molecule.
HemozoinMalariaChloroquineAntimalarial drug

Question 3:
What is the elimination half life of Chloroquine?
1 to 6 hours
1-2.6 hours
1-2 months
1-1.5 hours

Question 4:
What is the molecular weight of Chloroquine?
290.44
?
319.872 g/mol
318.449 g/mol

Question 5: The mechanisms behind the effects of chloroquine on ________ are currently being investigated.
CarcinogenesisCancerChemotherapyMetastasis

Question 6: Against rheumatoid arthritis, it operates by inhibiting lymphocyte proliferation, phospholipase A, release of ________ from lysosomes, release of reactive oxygen species from macrophages, and production of IL-1.
EnzymeEnzyme inhibitorProteinCofactor (biochemistry)

Question 7: Chloroquine caps ________ molecules to prevent further biocrystallization of heme, thus leading to heme buildup.
MalariaHemozoinOxygenAntimalarial drug

Question 8: As an antiviral agent, it impedes the completion of the viral life cycle by inhibiting some processes occurring within intracellular ________ and requiring a low pH.
MitochondrionCell nucleusOrganelleCell (biology)

Question 9: Inside red blood cells, the malarial parasite must degrade ________ to acquire essential amino acids, which the parasite requires to construct its own protein and for energy metabolism.
Serum ironArterial blood gasHemoglobinGlycated hemoglobin

Question 10: [9] The use of Chloroquine has also been associated with the development of ________.
Macular degenerationCentral serous retinopathyDiabetic retinopathyKeratoconus







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