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Chlordiazepoxide: Quiz


Question 1:
What is the chemical name of Chlordiazepoxide (IUPAC)
ethyl 7-chloro-5--2-oxo-1,3-dihydro-1,4-benzodiazepine-3-carboxylate
-7-Chloro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl pivalate
7- chloro- 2- methylamino- 5- phenyl- 3H- 1,4- benzodiazepine- 4- oxide

Question 2:
What is the molecular weight of Chlordiazepoxide?
12,103 g/mol
299.75 g/mol
380.42 g/mol
321.456 g/mol

Question 3: [4] In 1963, approval for use was given to ________ (Valium), a "simplified" version of chlordiazepoxide, primarily to counteract anxiety symptoms.

Question 4: ________ - plasma concentration of some benzodiazepines increased by fluvoxamine

Question 5:
What is the elimination half life of Chlordiazepoxide?
5–30 hours
.1 hr
6-8 hours
30 hrs

Question 6: Chlordiazepoxide has a medium to long ________ but its active metabolite has a very long half life.
Cosmic rayHalf-lifeRadioactive decayNuclear fission

Question 7: Benzodiazepines require special precaution if used in the elderly, pregnancy, children, alcohol- or drug-dependent individuals and individuals with comorbid ________.
SchizophreniaPsychiatryMental disorderICD-10 Chapter V: Mental and behavioural disorders

Question 8: Forty-two hospital patients admitted for acute and chronic alcoholism, and various ________ and neuroses were treated with chlordiazepoxide.
Major depressive disorderEating disordersPsychiatryPsychosis

Question 9: Severe liver deficiencies (hepatitis and liver ________ decrease elimination by a factor of 2)
Acute liver failureHepatic encephalopathyHepatorenal syndromeCirrhosis

Question 10: In a majority of the patients, anxiety, tension, and motor excitement were "effectively reduced." The most positive results were observed among ________ patients.
Drug addictionAlcoholismBenzodiazepineAddiction

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