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Cephalosporin: Quiz

  
  
  

Question 1: The cephalosporin nucleus, 7-aminocephalosporanic acid (7-ACA), was derived from cephalosporin C and proved to be analogous to the ________ nucleus 6-aminopenicillanic acid, but it was not sufficiently potent for clinical use.
PenicillinBeta-lactam antibioticCycloserineAntibiotic

Question 2: They are also more resistant to ________.
AntibioticAztreonamBeta-lactam antibioticBeta-lactamase

Question 3: Many can cross the ________ and are effective in meningitis.
Blood-brain barrierAIDSImmune systemBacteria

Question 4: ________ mimic this site and competitively inhibit PBP crosslinking of peptidoglycan.
CephalosporinBeta-lactam antibioticPenicillinCefotaxime

Question 5: Several cephalosporins are associated with hypoprothrombinemia and a ________-like reaction with ethanol.
DisulfiramIbogaineRadafaxineBupropion

Question 6: Ceftobiprole has powerful anti________ characteristics and appears to be less susceptible to development of resistance.
PseudomonasPseudomonas aeruginosaPseudomonas syringaeBacteria

Question 7: He noticed that these cultures produced substances that were effective against Salmonella typhi, the cause of typhoid fever, which had ________.
AztreonamBeta-lactam antibioticAntibioticBeta-lactamase

Question 8: [4] Hence it was commonly stated that they are contraindicated in patients with a history of severe, immediate allergic reactions (urticaria, ________, interstitial nephritis, etc) to penicillins, carbapenems or cephalosporins.
Serum sicknessAnaphylaxisAllergyGraft-versus-host disease

Question 9: Guy Newton and Edward Abraham at the ________ at the University of Oxford isolated cephalosporin C.
Howard Florey, Baron FloreySir William Dunn School of PathologyNorman HeatleyHerman Waldmann

Question 10: Cephalosporins are sometimes grouped into "generations" by their ________ properties.
AntibioticAntiviral drugAntibiotic resistanceAntimicrobial
















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