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Catechol-O-methyl transferase: Quiz


Question 1: Catechol-O-methyl transferase (COMT; EC is one of several enzymes that degrade catecholamines such as ________, epinephrine, and norepinephrine.

Question 2: COMT inhibitors include tolcapone and entacapone, which are commonly used in the treatment of ________.
HypersomniaParkinson's diseaseAlzheimer's diseaseHuntington's disease

Question 3: COMT is the name given to the ________ that codes for this enzyme.

Question 4: The link between impairments in these sorts of cognitive tasks and the COMT gene is thought to be mediated by an effect on dopamine signaling in the ________.
Frontal lobeInsular cortexCerebrumHuman brain

Question 5: Comparable effects on similar cognitive tasks, the frontal lobes, and the neurotransmitter dopamine have also all been linked to ________.
Major depressive disorderSchizophreniaBipolar disorderMental disorder

Question 6: This polymorphism in the COMT gene results in the substitution of the amino acid valine for methionine at ________ 158, thus the name Val158Met for the polymorphism.
Francis CrickDNAProteinGenetic code

Question 7: COMT was first discovered by the biochemist ________ in 1957.
Earl Wilbur Sutherland, Jr.George WaldJulius AxelrodArthur Kornberg

Question 8: Catechol-O-methyl transferase is involved in the inactivation of the catecholamine neurotransmitters (________, epinephrine, and norepinephrine).

Question 9: ________, a precursor of catecholamines, is an important substrate of COMT.

Question 10: Others are rs737865 and rs165599 that have been studied, e.g., for association with ________.
Trait theoryBig Five personality traitsPsychologyPersonality psychology

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