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Brain-derived neurotrophic factor: Quiz


Question 1: The BDNF protein is coded by the ________ that is also called BDNF.

Question 2: In 2009 variants close to the BDNF gene were found to associatate with obesity in two very large genome wide association studies of ________ (BMI).
MalnutritionEating disordersOverweightBody mass index

Question 3: BDNF acts on certain neurons of the ________ and the peripheral nervous system, helping to support the survival of existing neurons and encourage the growth and differentiation of new neurons and synapses.
Central nervous systemGrey matterWhite matterAlpha motor neuron

Question 4: ________ has been shown to increase the secretion of BDNF at the mRNA and protein levels in the rodent hippocampus, suggesting the potential increase of this neurotrophin after exercise in humans.
Strength trainingObesityPhysical exerciseMajor depressive disorder

Question 5: Neurotrophic factors are found in the ________ and the periphery.
Nervous systemDigestionSensory systemBrain

Question 6: Also, there are other neurotrophic factors structurally related to BDNF: NGF (for Nerve Growth Factor), ________ (for Neurotrophin-3) and NT-4 (for Neurotrophin-4).
Insulin-like growth factor 1Neurotrophin-3Brain-derived neurotrophic factorCalcitonin

Question 7: [4][5] In the brain, it is active in the ________, cortex, and basal forebrain—areas vital to learning, memory, and higher thinking.
CerebrumDentate gyrusHippocampusCingulate gyrus

Question 8: Although the vast majority of neurons in the mammalian brain are formed prenatally, parts of the adult brain retain the ability to grow new neurons from neural stem cells in a process known as ________.
Alzheimer's diseaseDopamineNeurogenesisDrug addiction

Question 9: The other BDNF receptor, the ________, plays a somewhat less clear role.
Insulin-like growth factor 1 receptorCD117Insulin-like growth factor 2 receptorLow-affinity nerve growth factor receptor

Question 10: While TrkB mediates the effects of BDNF and NT-4, TrkA binds and is activated by NGF, and TrkC binds and is activated by ________.
Brain-derived neurotrophic factorNeurotrophin-3Insulin-like growth factor 1Nerve growth factor


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