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Blood-brain barrier: Quiz


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Question 1: When Ehrlich injected some of these dyes (notably the aniline dyes that were then widely-used), the dye would stain all of the organs of some kinds of animals except for their ________.
DigestionNervous systemSensory systemBrain

Question 2: The blood-brain barrier (BBB) is a separation of circulating ________ and cerebrospinal fluid (CSF) maintained by the choroid plexus in the central nervous system (CNS).
PlateletBlood plasmaBloodRed blood cell

Question 3: ________) and large or hydrophilic molecules into the CSF, while allowing the diffusion of small hydrophobic molecules (O2, hormones, CO2).
Gram-positive bacteriaGram-negative bacteriaCorynebacteriumBacteria

Question 4: ________ (PML) is a demyelinating disease of the central nervous system that is caused by reactivation of a latent papovavirus (the JC polyomavirus) infection, that can cross the BBB.
Tropical spastic paraparesisPoliomyelitisHerpesviral encephalitisProgressive multifocal leukoencephalopathy

Question 5: Cells of the barrier actively transport ________ products such as glucose across the barrier with specific proteins.
Amino acidLipid metabolismMetabolism3-hydroxy-3-methylglutaryl-CoA lyase

Question 6: Instances of HIVE probably occur throughout the course of AIDS and are a precursor for ________ (HAD).
Alzheimer's diseaseCreutzfeldt–Jakob diseaseHuntington's diseaseAIDS dementia complex

Question 7: An exception to the bacterial exclusion are the diseases caused by spirochetes, such as Borrelia, which causes ________, and Treponema pallidum, which causes syphilis.
Pathogenic bacteriaICD-10 Chapter I: Certain infectious and parasitic diseasesLyme diseaseRelapsing fever

Question 8: The blood-brain barrier acts very effectively to protect the brain from many common bacterial ________.

Question 9: Other factors, such as ________, may contribute to the resistance of brain tumors to therapy.
AstrocyteGlial cellOligodendrocyteMicroglia

Question 10: ________ cell projections called astrocytic feet (also known as "glia limitans") surround the endothelial cells of the BBB, providing biochemical support to those cells.
OligodendrocyteMicrogliaAstrocyteGlial cell


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