| Question 1: Some common protracted withdrawal symptoms include ________, depression and insomnia and physical symptoms such as gastrointestinal, neurologic and musculoskeletal effects. | |||
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| Question 2: ________ of the hypothalamic-pituitary-adrenocortical axis also plays an important role in the severity of benzodiazepine withdrawal. | |||
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| Question 3: In an animal study of four ________ on low-dose benzodiazepine treatment, three out of the four baboons demonstrated physical dependence and developed flumazenil-precipitated withdrawal symptoms after only two weeks of low-dose benzodiazepine treatment. | |||
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| Question 4: [19] A physical dependence develops more quickly with higher potency benzodiazepines such as ________ (Xanax) than with lower potency benzodiazepines such as chlordiazepoxide (Librium). | |||
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| Question 5: ________ share a similar mechanism of action with various sedative compounds that act by enhancing the GABAA receptor. | |||
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| Question 6: Other changes which occur are the reduction of the number of GABA receptors (internalisation) as well as possibly long term changes in ________ coding of brain cells. | |||
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| Question 7: A survey in ________ of doctors found that many doctors feel that their training and knowledge of benzodiazepines is generally poor. | |||
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| Question 8: In ________, chronic, low-therapeutic-dose dependence was demonstrated in experimentally precipitated withdrawal using flumazenil to show physical dependence and withdrawal signs. | |||
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| Question 9: Benzodiazepine dependence at the ________ | |||
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| Question 10: Dependence can either be a psychological dependence (addiction) or a ________ or a combination of the two. | |||
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