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Benzodiazepine dependence: Quiz

  
  

Question 1: Some common protracted withdrawal symptoms include ________, depression and insomnia and physical symptoms such as gastrointestinal, neurologic and musculoskeletal effects.
HostilityAnxietyMental confusionEmotion

Question 2: ________ of the hypothalamic-pituitary-adrenocortical axis also plays an important role in the severity of benzodiazepine withdrawal.
Rebound effectInsomniaHypnoticBenzodiazepine withdrawal syndrome

Question 3: In an animal study of four ________ on low-dose benzodiazepine treatment, three out of the four baboons demonstrated physical dependence and developed flumazenil-precipitated withdrawal symptoms after only two weeks of low-dose benzodiazepine treatment.
Hamadryas BaboonCercopithecinaeBaboonGelada

Question 4: [19] A physical dependence develops more quickly with higher potency benzodiazepines such as ________ (Xanax) than with lower potency benzodiazepines such as chlordiazepoxide (Librium).
AlprazolamClorazepateLorazepamDiazepam

Question 5: ________ share a similar mechanism of action with various sedative compounds that act by enhancing the GABAA receptor.
PropofolBarbexacloneGABA reuptake inhibitorBenzodiazepine

Question 6: Other changes which occur are the reduction of the number of GABA receptors (internalisation) as well as possibly long term changes in ________ coding of brain cells.
DNATranscription (genetics)Gene expressionPost-transcriptional regulation

Question 7: A survey in ________ of doctors found that many doctors feel that their training and knowledge of benzodiazepines is generally poor.
MozambiqueCôte d'IvoireSenegalGuinea-Bissau

Question 8: In ________, chronic, low-therapeutic-dose dependence was demonstrated in experimentally precipitated withdrawal using flumazenil to show physical dependence and withdrawal signs.
MindHumanHuman evolutionHomo

Question 9: Benzodiazepine dependence at the ________
Open Directory ProjectTime WarnerJim BarksdaleLife (magazine)

Question 10: Dependence can either be a psychological dependence (addiction) or a ________ or a combination of the two.
Benzodiazepine dependenceBenzodiazepine withdrawal syndromeDrug abusePhysical dependence
















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