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Benzodiazepine: Quiz

  












Question 1: They can be very useful in intensive care to sedate patients receiving ________ or those in extreme distress.
Mechanical ventilationPositive airway pressureAcute respiratory distress syndromeShock (circulatory)

Question 2: [85][86] ________ are contraindicated during benzodiazepine withdrawal as they are cross tolerant with benzodiazepines and can induce dependence.
PyrithyldionePropofolPipofezineNonbenzodiazepine

Question 3: What does the following picture show?

  Schematic diagram of the (α1)2(β2)2(γ2) GABAA receptor complex that depicts the five-protein subunits that form the receptor, the chloride (Cl-) ion channel pore at the center, the two GABA active binding sites at the α1 and β2 interfaces and the benzodiazepine (BZD) allosteric binding site at the α1 and γ2 interface.
  Chlordiazepoxide 5 mg capsules, which are sometimes used as an alternative to diazepam for benzodiazepine withdrawal. Like diazepam it has a long elimination half-life and long-acting active metabolites.
  Benzodiazepines taken during pregnancy have adverse effects on the baby. Abrupt withdrawal in benzodiazepine dependent pregnant women may result in spontaneous abortions and provoke suicidal ideation.
  Adverse effects of benzodiazepines are increased and the benefits are decreased in the elderly. Adverse effects on cognition can be mistaken for the effects of old age.[98][99]

Question 4: If used in pregnancy, those benzodiazepines with a better and longer safety record, such as diazepam or chlordiazepoxide, are recommended over potentially more harmful benzodiazepines, such as ________ or triazolam.
ClorazepateOxazepamLorazepamAlprazolam

Question 5: [16][17] Following chlordiazepoxide, ________ was marketed by Hoffmann–La Roche under the brand name Valium in 1963, and for a while the two were the most commercially successful drugs.
ClorazepateDiazepamBenzodiazepineLorazepam

Question 6: [124] The symptoms of a benzodiazepine overdose may include; drowsiness, slurred speech, nystagmus, hypotension, ________, coma, respiratory depression and cardiorespiratory arrest.
AtaxiaRestless legs syndromeIntention tremorTremor

Question 7: Psychological therapies such as ________ are recommended as a first line therapy for panic disorder; benzodiazepine use has been found to interfere with therapeutic gains from these therapies.
Edna B. FoaImpulse (psychology)Cognitive behavioral therapyThought suppression

Question 8: What does the following picture show?

  A pharmacophore model of the benzodiazepine binding site on the GABAA receptor.[112] White sticks represent the carbon atoms of the benzodi-azepine diazepam while green represents carbon atoms of the nonbenzodiazepine CGS-9896. Red and blue sticks are oxygen and nitrogen atoms that are present in both structures. The red spheres labeled H1 and H2/A3 are respectively hydrogen bond donating and accepting sites in the receptor while L1, L2, and L3 denote lipophilic binding sites.
  Benzodiazepines taken during pregnancy have adverse effects on the baby. Abrupt withdrawal in benzodiazepine dependent pregnant women may result in spontaneous abortions and provoke suicidal ideation.
  Schematic diagram of the (α1)2(β2)2(γ2) GABAA receptor complex that depicts the five-protein subunits that form the receptor, the chloride (Cl-) ion channel pore at the center, the two GABA active binding sites at the α1 and β2 interfaces and the benzodiazepine (BZD) allosteric binding site at the α1 and γ2 interface.
  The molecular structure of chlordiazepoxide, the first benzodiazepine. It was marketed by Hoffmann–La Roche from 1960 branded as Librium.

Question 9: ________ such as zaleplon and zolpidem and low doses of sedating antidepressants are sometimes used as alternatives to benzodiazepines.
PyrithyldionePipofezinePropofolNonbenzodiazepine

Question 10: [134] Benzodiazepines are sometimes used for criminal purposes; they serve to incapacitate a victim in cases of ________ or robbery.
SedativeDate rape drugFlunitrazepamAlcoholic beverage
















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