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Aromatase inhibitor: Quiz


Question 1: • An increase in the incidence of ________ and fractures (specifically fractures of spine, hip and wrist).
Osteochondritis dissecansOsteitis fibrosa cysticaOsteopeniaOsteoporosis

Question 2: Aromatase inhibitors (AI) are a class of drugs used in the treatment of ________ and ovarian cancer in postmenopausal women.
Breast cancer classificationBreast cancerLung cancerMammary ductal carcinoma

Question 3: The other main source of estrogen post-menopausally is ________[citation needed].
CollagenAdipose tissueBrown adipose tissueAdipocyte

Question 4: ________ are sometimes prescribed to prevent the osteoporosis induced by aromatase inhibitors but have another serious side effect, osteonecrosis of the jaws.
ChemotherapyIntravenous immunoglobulinBisphosphonateH2 antagonist

Question 5: ________ (especially without 5-alpha-reductase inhibitor)
HyperlipidemiaHypercholesterolemiaHypertriglyceridemiaFamilial hypercholesterolemia

Question 6: Since ________ have a bone strengthening effect [9], combining a statin with an aromatase inhibitor may avoid both fractures and possible cardiovascular risks [10] without jaw osteonecrosis.
StatinFibrateBile acid sequestrantHypolipidemic agent

Question 7: ________ has been standard treatment, however the ATAC trial has shown that clinical results are superior with an AI in postmenopausal women with localized breast cancer that is estrogen receptor positive.

Question 8: Aromatase inhibitors work by inhibiting the action of the enzyme aromatase, which converts ________ into estrogens by a process called aromatization.

Question 9: [11] In one study of women with breast cancer taking anastrozole, statin use was associated with a 38% reduced fracture risk, or approximately the equivalent of 10 mg ________ daily.
LosartanAlendronic acidSimvastatinEzetimibe

Question 10: In contrast to pre-menopausal women, in whom most of the estrogen is produced in the ovaries, in post-menopausal women most of the body's estrogen is produced in the ________ from the conversion of androgens.
TesticleEndocrine systemAdrenal glandThyroid

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