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Amphotericin B: Quiz


Question 1:
What is the elimination half life of Amphotericin B?
19-24 hours
2–4 hours
22 - 24 hs
initial phase : 24 hours,

Question 2:
How is Amphotericin B excreted?
40% found in urine after single cumulated over several days
Urine, within 24 hours
faecal 47%

Question 3: In the circulatory system, several forms of anemia and other blood dyscrasias (leukopenia, thrombopenia), serious cardiac ________ (including ventricular fibrillation), and even frank cardiac failure have been reported.
Supraventricular tachycardiaMyocardial infarctionCardiac dysrhythmiaAtrial fibrillation

Question 4: AmBisome is a liposomal formulation of amphotericin B for injection, developed by NeXstar Pharmaceuticals (acquired by ________ in 1999).
StarbucksGilead SciencesIntel CorporationDell

Question 5: corticosteroids acting locally (Prednisolone, ________, Prednisone, Betamethasone, Tixocortol, Budesonide, Beclometasone)

Question 6: An increase in ________-synthesis may also play a role.
ProstaglandinProstaglandin analogueOxytocinEpinephrine

Question 7: Another IV use is as a drug of last resort in otherwise untreatable parasitic protozoan infections such as visceral leishmaniasis[1][2] and ________.
PoliomyelitisAmoebic brain abscessAlzheimer's diseasePrimary amoebic meningoencephalitis

Question 8: ________citronella oillemon grassorange oilpatchoulilemon myrtle
Tea tree oilSalicylic acidAmphotericin BClotrimazole

Question 9: It was originally extracted from Streptomyces nodosus, a filamentous bacterium, in 1955 at the Squibb Institute for Medical Research from cultures of an undescribed streptomycete isolated from the soil collected in the ________ region of Venezuela.
Rio Negro (Amazon)Puerto AyacuchoOrinocoAmazon River

Question 10: Amphotericin B (Fungilin, Fungizone, Abelcet, AmBisome, Fungisome, Amphocil, Amphotec) is a polyene ________ drug, often used intravenously for systemic fungal infections.
Pharmaceutical drugAntifungal drugAntibioticAntiviral drug

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