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Amitriptyline: Quiz


Question 1:
What is the elimination half life of Amitriptyline?
10u201350 hours, with an average of 15 hours
1.5 to 2.7 hours
15-18 hours
12h average for d-isomer, 13h for l-isomer

Question 2:
What is the chemical name of Amitriptyline (IUPAC)
3-- N,N-dimethyl- 1-propanamine''
4-morpholin-4-ylbutan-2-yl 4-phenyloxane-4-carboxylate

Question 3: [18] It promotes the heterodimerization of these ________ in the absence of NGF and has potent neurotrophic activity both in-vivo and in-vitro in mouse models.

Question 4: A randomized controlled trial published in June 2005 found that amitriptyline was effective in ________ that did not respond to a first-line treatment (famotidine or mosapride).
Gastroesophageal reflux diseaseDiarrheaDyspepsiaHepatitis

Question 5: Amitriptyline is used in ________ for pain relief and in some European countries it is officially approved as a preventive for patients with frequent/chronic migraines, usually 25 to 75 mg.
Rheumatoid arthritisSpondyloarthropathyAnkylosing spondylitisArthritis

Question 6: Amitriptyline (Elavil, Tryptizol, Laroxyl) is a ________ (TCA).
TrimipraminePipofezineTetracyclic antidepressantTricyclic antidepressant

Question 7: [10] [11][12][13] It has also been shown to be a relatively weak ________ negative allosteric modulator at the same binding site as phencyclidine.
Glutamate receptor5-HT receptor5-HT3 receptorNMDA receptor

Question 8: Amitriptyline in low doses is also sometimes prescribed to help ease the symptoms of ________.
Chronic fatigue syndromeMultiple sclerosisLyme diseaseSystemic lupus erythematosus

Question 9: Amitriptyline, under the brand name Elavil, was approved on April 7, 1961 for the treatment of major depression in the ________.
CanadaPhilippinesUnited StatesAlaska

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