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Amiodarone: Quiz

  
  

Question 1:
What is the chemical name of Amiodarone (IUPAC)
8--1-oxa-3,8-diazaspiro4.5decan-2-one
2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile
-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-13-en-5-ol
diethylamine

Question 2: In these cases, amiodarone can be used regardless of the individual's underlying heart function and the type of ventricular tachycardia; it can be used in individuals with ________ as well as individuals with polymorphic ventricular tachycardia.
Myocardial infarctionHypertrophic cardiomyopathyVentricular tachycardiaAtrial fibrillation

Question 3:
How is Amiodarone excreted?
Urine, within 24 hours
Renal: 93%
Primarily Hepatic and Biliary
Renal, very slow

Question 4:
What is the molecular weight of Amiodarone?
380.42 g/mol
269.345 g/mol
211.219 g/mol
645,31 g/mol

Question 5: Amiodarone was initially developed in 1961 at the Labaz company, ________, by chemists Tondeur and Binon.
BelgiumDenmarkUnited KingdomSpain

Question 6: amiodarone remained unapproved by the Food and Drug Administration, and physicians were forced to directly obtain amiodarone from pharmaceutical companies in ________ and Europe.
BarbadosUnited StatesUnited KingdomCanada

Question 7: The pharmacokinetics of numerous drugs, including many that are commonly administered to individuals with ________ disease, are affected by amiodarone.
Circulatory systemTorsoHeartLymphatic system

Question 8: In the ARCH trial, ________ amiodarone (2 grams administered over 2 days) has been shown to reduce the incidence of atrial fibrillation after open heart surgery when compared to placebo.
EnemaIntraosseous infusionCream (pharmaceutical)Intravenous therapy

Question 9: The most specific test of pulmonary toxicity due to amiodarone is a dramatically decreased DLCO noted on ________.
Bronchial hyperresponsivenessSpirometryBronchial challenge testLung volumes

Question 10: Individuals taking both of these medications should have their warfarin dose halved and their anticoagulation status (measured as prothrombin time (PT) and ________ (INR)) measured more frequently.
Partial thromboplastin timeD-dimerBlood plasmaProthrombin time
















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