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Amantadine: Quiz


Question 1:
What is the chemical name of Amantadine (IUPAC)

Question 2:
What is the elimination half life of Amantadine?
10-14 hours, in renal impairment up to 7-10 days
7 to 12.8 hours
3-7 hours
At steady state 7 hours

Question 3: Amantadine is the ________ known formally as 1-aminoadamantane.
CarbonBiochemistryOrganic chemistryOrganic compound

Question 4: Amantadine may be prepared by reacting adamantane with ________ or nitric acid to give the bromide or nitroester at the 1- position.

Question 5: Food and Drug Administration in October 1966 as a prophylactic agent against Asian influenza and eventually received approval for the treatment of ________[1][2][3][4] in adults.
Influenzavirus BInfluenza A virusAvian influenzaInfluenzavirus C

Question 6: The drug has many effects in the brain, including release of ________ and norepinephrine from nerve endings.

Question 7: Amantadine has been associated with several ________ side effects, likely due to amantadine's dopaminergic and adrenergic activity, and to a lesser extent, its activity as an anticholinergic.
NeuronGrey matterWhite matterCentral nervous system

Question 8: Another potential side effect is livedo reticularis, a ________ reaction that results in skin mottling and purpurish mesh network of blood vessels.
ImmunologySurgeryPlastic surgeryDermatology

Question 9: It appears to be a weak ________[17] as well as an anticholinergic.
KetamineNMDA receptor antagonistDizocilpineAmpakine

Question 10: The molecule consists of adamantane backbone that is substituted at one of the four methyne positions with an ________ group.

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