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Alpha 1-antitrypsin deficiency: Quiz

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Question 1: It is a leading cause of ________ in newborns.
Pancreas transplantationICD-9-CM Volume 3SurgeryLiver transplantation

Question 2: A1AD was discovered in 1963 by Carl-Bertil Laurell (1919–2001), at the University of Lund in ________.
DenmarkSwedenEstoniaFinland

Question 3: ________ smoke is especially harmful to individuals with A1AD.
Tobacco smokingSmokingCigaretteTobacco advertising

Question 4: The link with ________ was made six years later, when Sharp et al. described A1AD in the context of liver disease.
Esophageal diseasePancreatic diseaseStomach diseaseLiver disease

Question 5: Other experimental therapies are aimed at the prevention of polymer formation in the ________.
PancreasLiverEndocrine systemImmune system

Question 6: The patient's symptoms may resemble recurrent respiratory infections or ________ that does not respond to treatment.
AsthmaAllergic bronchopulmonary aspergillosisFarmer's lungHypersensitivity pneumonitis

Question 7: Please see ________ for a discussion of the various genotypes and phenotypes associated with A1AD.
AntithrombinAlpha 2-antiplasminAlpha 1-antichymotrypsinAlpha 1-antitrypsin

Question 8: ________ (COPD)
BronchiectasisAsthmaChronic obstructive pulmonary diseasePneumonia

Question 9: A1AD also causes impaired liver function in some patients and may lead to ________ and liver failure (15%).
Acute liver failureHepatorenal syndromeCirrhosisHepatitis

Question 10: A ________ in such cases will reveal PAS-positive, diastase-negative granules.
Hepatitis CColorectal cancerCancerLiver biopsy







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