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Alemtuzumab: Quiz

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Question 1: A significant complication of therapy with alemtuzumab is that it significantly increases the risk for opportunistic infections, in particular, reactivation of ________.
Hepatitis BAIDSCytomegalovirusErythema infectiosum

Question 2: It is also used under ________ protocols for treatment of some autoimmune diseases, such as multiple sclerosis, in which it shows promise.
Medical researchClinical trialClinical trial protocolPlacebo-controlled study

Question 3: bcr-abl (Dasatinib, ________, Nilotinib)
SildenafilClozapineImatinibAripiprazole

Question 4: Alemtuzumab targets CD52, a protein present on the surface of mature ________, but not on the stem cells from which these lymphocytes are derived.
LymphocyteAdaptive immune systemThymocyteImmune system

Question 5: lymphoid: ________ (Ibritumomab, Ofatumumab, Rituximab, Tositumomab)
CD4CD14CD11cCD20

Question 6: Alemtuzumab (marketed as Campath, MabCampath or Campath-1H) is a monoclonal antibody used in the treatment of ________ (CLL), cutaneous T-cell lymphoma (CTCL) and T-cell lymphoma.
B-cell chronic lymphocytic leukemiaHairy cell leukemiaHodgkin's lymphomaAcute lymphoblastic leukemia

Question 7: Alemtuzumab is also used in some conditioning regimens for ________ and kidney transplantation.
Hematopoietic stem cell transplantationGraft-versus-host diseaseImmunosuppressive drugOrgan transplant

Question 8: It is also possible that perturbation of suppressor T cell populations by Campath-1H may precipitate ________.
AutoimmunityImmune disorderHypersensitivityAutoimmune disease

Question 9: Early tests at ________ suggest that alemtuzumab might be useful in treating and even reversing the effects of multiple sclerosis.
University of OxfordUniversity of EdinburghUniversity of CambridgeUniversity of Bristol







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