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Adrenocorticotropic hormone: Quiz

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Question 1: ACTH Stimulates cholesterol ________, which makes the rate-limiting step in steroidogenesis.
Steroid 11-beta-hydroxylaseCholesterol side-chain cleavage enzyme21-HydroxylaseAldosterone synthase

Question 2: Upon ligand binding, the receptor undergoes conformation changes that stimulate the enzyme adenylyl cyclase, which leads to an increase in intracellular cAMP and subsequent activation of ________.
G protein-coupled receptor kinaseAMP-activated protein kinaseProtein kinase CProtein kinase A

Question 3: ACTH is also related to the ________ in many organisms.
Suprachiasmatic nucleusCircadian rhythmMelatoninChronobiology

Question 4: An active synthetic form of ACTH, consisting of the first 23 amino acids of native ACTH, was first synthesized by Klaus Hofmann at the ________.
Carnegie Mellon UniversityUniversity of PittsburghPittsburgh PanthersHeinz Field

Question 5: ________ secreted from the adrenal cortex work to inhibit CRH secretion by the hypothalamus, which in turn decreases anterior pituitary secretion of ACTH.
MineralocorticoidCorticosteroidImmunosuppressive drugGlucocorticoid

Question 6: POMC, ACTH and β-lipotropin are secreted from corticotropes in the anterior lobe (or adenohypophysis) of the pituitary gland in response to the hormone ________ (CRH) released by the hypothalamus.
ProopiomelanocortinOxytocinGonadotropin-releasing hormoneCorticotropin-releasing hormone

Question 7: The ________ of ACTH in human blood is about ten minutes.
Radioactive decayNuclear fissionHalf-lifeCosmic ray

Question 8: This increases the bio-availability of ________ in the cells of the adrenal cortex.
AtherosclerosisCholesterolTrans fatLow-density lipoprotein

Question 9: Both are very rarely used in place of glucocorticoids to treat secondary adrenal insufficiency in a hospital setting, but are primarily used to conduct the ________.
AldosteroneHuman physiologyACTH stimulation testRenin

Question 10: This results in the synthesis and secretion of gluco- and mineralo-________, and androgenic steroids.
Sex steroidGlucocorticoidCorticosteroidMineralocorticoid







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