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Actinomycin: Quiz


Question 1: Actinomycin D and its fluorescent derivative, 7-aminoactinomycin D (7-AAD), are used as stains in microscopy and ________ applications.
InflammationHistopathologyImmunohistochemistryFlow cytometry

Question 2: It was the first antibiotic isolated by ________ and his co-worker H.
Salvador LuriaFrancis CrickSelman WaksmanJames D. Watson

Question 3: thymidylate synthase inhibitor (________, Capecitabine, Tegafur, Carmofur, Floxuridine)

Question 4: It was the first antibiotic shown to have anti-________ activity, but is not normally used as such, as it is highly toxic, causing damage to genetic material.

Question 5: [2] Because it can bind DNA duplexes, it can also interfere with ________, although other chemicals such as hydroxyurea are better suited for use in the laboratory as inhibitors of DNA synthesis.
Replication forkDNA replicationTelomerasePrimer (molecular biology)

Question 6: It does this by binding ________ at the transcription initiation complex and preventing elongation by RNA polymerase.

Question 7: halogenated/ribonucleotide reductase inhibitors (________, Clofarabine, Fludarabine)

Question 8: The actinomycins are a class of polypeptide antibiotics isolated from soil bacteria of the genus ________, of which the most significant is actinomycin D.
VancomycinStreptomycesAmphotericin BChloramphenicol


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