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AMPA receptor: Quiz


Question 1: For example, GluR1 binds to SAP97 through SAP97's class I PDZ domain[7], while GluR2 binds to ________[8] and GRIP/ABP.

Question 2: There are two necessary components of LTP: presynaptic ________ release, and postsynaptic depolarization.
Glutamic acidDizocilpineGlutamineNitrous oxide

Question 3: ________ of AMPARs can regulate channel localization, conductance, and open probability.
UbiquitinAmino acidPhosphorylationPosttranslational modification

Question 4: S818 is phosphorylated by PKC, and is necessary for ________ (LTP; for GluR1's role in LTP, see below).
Long-term depressionNervous systemMemoryLong-term potentiation

Question 5: Here, editing alters the uncharged ________ glutamine (Q), to the positively-charged arginine (R) in the receptor's ion channel.
Amino acidL-DOPAMetabolismAmino acid synthesis

Question 6: AMPARs are found in many parts of the ________ and are the most commonly found receptor in the nervous system.
Sensory systemDigestionBrainEndocrine system

Question 7: Of note, AMPARs cannot directly bind to the common synaptic protein ________ due to incompatible PDZ domains.

Question 8: Glutamate binds to postsynaptic AMPARs and another glutamate receptor, the ________ (NMDAR).
NMDA receptor5-HT3 receptorNicotinic acetylcholine receptor5-HT receptor

Question 9: The conformation of the subunit protein in the ________ caused controversy for some time.
Cell nucleusCell (biology)Vesicle (biology)Cell membrane

Question 10: [4][5] Dimerization starts in the ________ with the interaction of n-terminal LIVBP domains, then "zips up" through the ligand binding domain into the transmembrane ion pore.
Endomembrane systemEndoplasmic reticulumGolgi apparatusCell (biology)


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