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5-HT3 antagonist: Quiz

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Question 1: The 5-HT3 antagonists are a class of medications that act as receptor antagonists at the 5-hydroxytryptamine-3 receptor (5-HT3 receptor), a subtype of serotonin receptor found in terminals of the vagus nerve and in certain areas of the ________.
DigestionNervous systemSensory systemBrain

Question 2: An optimal environment of the basic nitrogen is when its constrained within an azabicyclin system with the highes affinity observed for systems with nitrogen at the bridgehead position and secondary ________ being more potent.
AlcoholPyridineAmineAmide

Question 3: [4] The extracellular domain is the site of action of agonists and competitive antagonists because of ligand binding and the transmembrane domain controls the movement of ions across the ________.
Cell (biology)Cell membraneCell nucleusVesicle (biology)

Question 4: [27][28][29] A randomized, placebo-controlled trial of ondansetron to treat motion sickness in ________ personnel showed subjective improvement, but it was not statistically significant.
Medical directorAir ambulanceEmergency medical servicesParamedic

Question 5: The first-generation 5-HT3 receptor antagonist (ondansetron, dolasetron, granisetron, and tropisetron) have been the most important drugs in antiemetic therapy for emetogenic ________.
AntineoplasticChemotherapyATC code LCancer immunotherapy

Question 6: [4] The rapidly activating, desensitizing, inward current is predominantly carried by sodium and ________ ions.
ZincPotassiumCalciumAluminium

Question 7: HTR3A and HTR3B for the 5-HT3A and 5-HT3B subunits and in addition HTR3C, HTR3D and HTR3E ________ encoding 5-HT3C, 5-HT3D and 5-HT3E subunits.
GeneticsEvolutionDNAGene

Question 8: [45] In animal studies, ramosetron was also effective against ________-like symptoms.
Irritable bowel syndromeCrohn's diseaseCoeliac diseaseConstipation

Question 9: The pharmacophore of 5-HT3receptors consists of three components: a carbonyl-containing linking moiety, ________/heteroaromatic ring, and a basic center.
Covalent bondChemical bondAromaticityConjugated system

Question 10: Transporter [________]: Enhancer (RE) • Inhibitor (RI) • Releaser (RA)
ReuptakeDopamineGlutamic acidMonoamine neurotransmitter







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